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This Concept Map, created with IHMC CmapTools, has information related to: Class discussion Chapter 12, Promotor which is evidence that Cancer-causing Mutagenesis, Exogeneous mutagen errors are repaired by Base-excision repair, Endogenous biochemical errors include those caused by Depyrimidination, Hereditary non- polyposis colon cancer (HNPCC) caused by error in Mismatch repair, Reactive Oxygen Species are released by Peroxisomes, Nucleotide- excision repair differs from Mismatch repair, Strand nicks to determine Newly synthesized strand, T-T are more common to Occur, Karotype will not change due to Epigenetics, Transversion i.e. G->T replacement, Proofreading occurs by DNA polymerase, Mismatch repair looks for Strand nicks, Endogenous biochemical errors include those caused by Deamination, Karotype changed through Chromosome structure, Endogenous biochemical errors include those caused by Reactive Oxygen Species, Exogeneous mutagen errors include those caused by UV radiation, UV radiation causes covalent bonds (dimerization) between Pyrimidines, Chemical agents and include Electrophillic agents, Pyrimidines e.g. C-C, Replication errors repaired by Mismatch repair