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This Concept Map, created with IHMC CmapTools, has information related to: chapter 14-1, primary tumors can be benign, peritoneal / pleural space eg no pain or change in function, metastatic cells can pinch off cytoplasm to intravasate, primary tumors expand in liver/pancreas tumors, metastatic cells are not easily deformed, metastatic cells can collect platelets to hide in blood, primary tumors expand in peritoneal / pleural space, benign can become malignant, malignant eg become able to perform intravasation, metastatic cells can become stuck in capillaries, colon ex: disrupt passage thru colon eg digestion is affected, micrometastases can become macrometastases, become stuck in capillaries can lead to extravasation, capillaries have a diameter of 3-8 um, malignant eg breach basement membrane, metastatic cells move through capillaries, metastatic cells harvest growth and survival factors from ECM, primary tumors can be malignant, liver/pancreas tumors eg ducts are blocked, metastatic cells can get stuck in capillaries