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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 08 Discussion, Smad3 inhibits Myc, PI3K Pathway regulates Akt/PKB, Hyperphosphorylation is excess Phosphorylation, Oncoprotein eg Myc, G_1 is when cell is responsive to Extracellular Signaling, TGF-beta promotes Growth, Smad3 associates with E2F, Ras controls PI3K Pathway, p21cip1 inhibits Cyclin D Complexes, Cyclin D eg D1, Cyclin D phosphorylate pRb, Cyclin-Dependent Kinases (CDKs) are of type Ser/Thr, TGF-beta drives Cell Cycle, Max together promote advance through early G_1, Cyclins eg Cyclin D, TGF-beta drives Differentiation, TGF-beta primarily targets p15INK4B, Transcription Factor eg E2F, Cell Cycle is regulated by Checkpoints, CDK 4/6 is only activated around Cyclin D