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This Concept Map, created with IHMC CmapTools, has information related to: Section 14.2, colonization is the rate-limiting determinant, genetic heterogeneity portrayed by a dendrogram, lymph node detect micrometastases, genetic heterogeneity that shows evolution of colonization, micrometastases are revealed through organ transplantation, marrow detect micrometastases, micrometastases have genetic heterogeneity, micrometastases ex solitary dormant tumor cells, rate-limiting determinant of invasion-metastasis cascade, colonization is the most complex and challenging step of the invasion-metastasis cascade, cytokeratins in a marrow, micrometastases show that metastatic ability, cytokeratins in a lymph node, metastatic ability can evolve outside of the primary tumor, solitary dormant tumor cells persist many weeks in the liver, colonization is responsible for metastatic inefficiency