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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 14 sections 3,6,9,12, loss of E-cadherin expression can act as a marker for an EMT, metastasis suppressor genes regulate carcinoma cell invasion, colonize and develop into a macrometastases, micrometastases typically arise after primary tumor removal, macrophage recruitment leads to release of MMPs, pro-uPA binds to and is activated by uPAR, colonization happens in non-random organ sites, cytokeratins in a lymph node, "seed and soil" hypothesis does not explain contralateral metastases, MMPs if constitutively expressed, micrometastases show that metastatic ability, micrometastases are the first steps of carcinoma cell invasion, stromal cells release pro-uPA, MMPs degrade the ECM, "seed and soil" hypothesis is dependent upon a permissive environment for completion, EMT leads to micrometastases, podosomes are used during tumor cell invasion, EMT permits carcinoma cells to become invasive, acquire the ability to colonize, extracellular proteases enable carcinoma cell invasion