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This Concept Map, created with IHMC CmapTools, has information related to: chapter 14-10, ECM contains large amounts of mitogenic/trophic factors, ET-1 endothelin 1 stimulates ET-1 receptor, osteoclasts eg cell that breaks down mineralized bone, apatite crystals can be protected by bisphosphonates, prostate cancer cells releases ET-1 endothelin 1, osteotropic metastasis eg metastasis to bone marrow, bone composition ex ECM, bone composition ex osteoclasts, breast cancer causes secretion of PTHrP parathyroid hormone-related protein, osteoblasts release ET-1 endothelin 1, demineralizes bone eg dissolve calcium phosphate crystals, ET-1 endothelin 1 suppresses osteoclasts, breast milk formation causes secretion of PTHrP parathyroid hormone-related protein, osteolytic metastasis can be slowed by OPG derivatives, cell that breaks down mineralized bone eg demineralizes bone, osteoclasts cause osteolytic metastasis, osteoblasts can activate or suppress osteoclasts, metastasis to bone marrow eg bone composition, prostate cancer cells express ET-1 receptor, ET-1 endothelin 1 stimulates osteoblasts