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This Concept Map, created with IHMC CmapTools, has information related to: Discussion, Genomic Instability e.g. Chromosomal Fusion, Tumor Associated Macrophages(TAM) secrete EGF, Genomic Instability e.g. Ras, Tumor Associated Macrophages(TAM) undergo Heterotypic Signaling, E-Cadherins when lost frees up B-Catenin, EGF increases Proliferate, EMT reduces expression of E-Cadherins, Stromal Cells undergo Heterotypic Signaling, EMT can be induced by Slug, EMT induces expression of N-Cadherin, Genomic Instability e.g. p53, Metastasis represent a complex system of steps e.g. intravasation, Metastasis is responsible for creating MicroMetastasis', Wound Healing/Inflammation causes recruitment of Tumor Associated Macrophages(TAM), Metastasis represent a complex system of steps e.g. EMT, MMP's cause release of Growth Factors, Metastasis represent a complex system of steps e.g. MET, Metastasis can be characterized by Genomic Instability, EMT is normally used for Embryogenesis, Ras oncogene can induce EMT