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This Concept Map, created with IHMC CmapTools, has information related to: Class discussion Chapter 14, Breast cancer lines binds Promoter, Carcinoma cells secrete CSF-1, Platelets are ignored by Macrophages, TGF-Beta recruits Macrophages, Fluorescence tagging can show Metastatic invasion, Colonize to form Macrometastasis, Primary tumor then proceeds to Localized invasation, Epithelial markers i.e. Beta- and Gamma-catenin, Capillaries have a diameter of 8 microns, Macrophages secrete EGF, Collagen layer only when Co-cultured, Twist is a Transcription factor, EMT causes gain of Mesenchymal markers, Pushing through of large tumor mass is a form of Localized invasation, Hepatocyte Growth Factor (HGF induces Motility, Cytokeratin staining can detect presence of Micrometastesis, Channel carving is a form of Localized invasation, Metastatic Tumor cells attract Platelets, Arrest in microvessels particulary in the brain, Platelets form Blood clots