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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 12, DNA mutations can be fixed by DNA repair, multi-drug resistance prevent mutations in hematopoietic stem cells, defense mechanisms that are physical, endogenous mutagens e.g. tobacco, endogenous mutagens e.g. depyrimidination, multiprotein nucleotide-excision repair (NER) complex are mutated in the Cockayne syndrome (CS), nonconserved strand which is retained in differentiated cells, DNA repair may include error-prone repair, microsatellite instability which yields a mutant TGF-beta receptor, endogenous mutagens e.g. depurination, DNA mutations may occur in stem cells, stem cells differentiate into transit-amplifying cells, physical barriers prevent mutations in hematopoietic stem cells, apoptosis induction prevent mutations in hematopoietic stem cells, DNA mutations can be avoided by employing defense mechanisms, DNA repair may include proofreading, asymmetric DNA replication prevent mutations in hematopoietic stem cells, conserved strand which is retained in stem cells, karyotype such as changes in structure, endogenous mutagens e.g. deamination