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This Concept Map, created with IHMC CmapTools, has information related to: 05. One carbon metabolism, Glycine or alterntely... Deaminated, Folic Acid made by Micro organisms, S-adenosylmethionine (SAM) Once donated, left over is S-adenosyl homocystein, 5,10 Methylene THF Synthesize from Glycine, Intercoversion requires B6, N5 can be in Multiple oxication states, High Levels especially when Given high levels of HIS, histidine degradation ultimately gltamate, homocysteine note... used in synthesis of Cysteine, Tetrahydrofolate (THF) properties Interconvertable, Micro organisms in the presence of p-aminobenzoic acid (PABA), B12 Deficiency Methyl trap, Cancer note Toxic to ALL cells (inhibits pyrmidine synthesis), CBS Enzyme deficiency results in homocystinuria (too much homocysteine), Cofactors either NADP, dihydrofolate Reductase (DFR) inhibited by Methotrexate, Tetrahydrofolate (THF) Source of carbons Serine, Tetrahydrofolate (THF) Source of carbons Glycine, 5,10 Methenyl THF which can be converted to 5,10 Methylene THF, Tetrahydrofolate (THF) Source of carbons Formate