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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 14, secondary site influences the probability of metastasis, basement membrane is a specialized type of ECM, stromal cells e.g. macrophages, intravasation is followed by extravasation, melanoma cell expresses N-cadherin, epithelial cells via autocrine signaling, stromal cells e.g. inflammatory cells, melanocyte to melanoma cell, melanocyte interacts with stromal cells, epithelial cells via paracrine signaling, EMT transition is controlled by TGF-beta, embryogenesis specifically gastrulation, metastasis involves intravasation, stromal cells e.g. fibroblasts, cancer cells communicate with tumor-associated macrophages (TAMs), tumor-associated macrophages (TAMs) via heterotypic signaling, cancer cells mimic wound healing, intravasation occurs after penetration of cells through the basement membrane, blood vessels via pinching off their cytoplasm, extravasation involves pushing of cancer cells through the basement membrane