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This Concept Map, created with IHMC CmapTools, has information related to: Ganesh, Lack of Function inhibits Inflammation, Morphology measured by Histopathology, Radiologically including Plane films, Morphology measured by uCT, Biochemistry including Metabolism, Biomechanical Function including Morphology, Metabolism measured by ISHH, IL--1 is a Pro-inflammatory Cytokine, Annulus including Biomechanical Function, IL-1 Receptor promoting Inflammation, IL--1 binds to IL-1 Receptor, Biochemistry including Morphology, Gene to infer Lack of Function, IL-1 Receptor Antagonist inhibits Inflammation, Spines and Tails with Intervertebral Discs, Mice models for Knocking Out, Annulus including Biochemistry, Disc Disease defined as Loss of Disc Height, Intervertebral Discs develop Disc Disease, Biomechanical Function including Metabolism