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This Concept Map, created with IHMC CmapTools, has information related to: Ganesh, Morphology measured by Histopathology, Nucleus surrounds Annulus, Radiologically including Plane films, Morphology measured by uCT, Biochemistry including Metabolism, Biomechanical Function including Morphology, Metabolism measured by ISHH, IL--1 is a Pro-inflammatory Cytokine, Annulus including Biomechanical Function, IL-1 Receptor promotes Inflammation, Pro-inflammatory Cytokine promotes Inflammation, IL--1 binds to IL-1 Receptor, Biochemistry including Morphology, Gene to infer Lack of Function, IL-1 Receptor Antagonist inhibits Inflammation, Spines and Tails with Intervertebral Discs, Mice models for Knocking Out, Annulus including Biochemistry, Disc Disease defined as Loss of Disc Height, Lack of Function promotes Inflammation