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This Concept Map, created with IHMC CmapTools, has information related to: antidotes for toxic agents - CN poisoning, hypoxia also causes but cyanosis, CN poisoning symptoms/ signs are bitter almond breath (half of people can't sense), CN poisoning sources are by-product of nitroprusside > 10ug/kg/min, CN poisoning treatment 2. sodium thiosulfate (i.v.), 3. methylene blue reduces Hb (Fe3+) methemoglobin --> Hb (Fe2+), CN poisoning symptoms/ signs are metabolic acidosis, CN poisoning sources are plant seeds -almonds -apricots, CN poisoning treatment 3. methylene blue, CN poisoning treatment <math xmlns="http://www.w3.org/1998/Math/MathML"> <mtext> 1. amyl nitrite </mtext> </math>, CN poisoning mechanism CN has high aff for Fe3+, metabolic acidosis also causes but cyanosis, CN poisoning sources are burning plastics, CN poisoning diagnosed by, Fe3+ of cytochrome oxidase, thereby halting ETC and ATP production resulting in hypoxia, CN poisoning symptoms/ signs are headache, rapid coma, seizures; death from resp failure, Fe3+ of cytochrome oxidase, thereby halting ETC and ATP production resulting in compensation by anaerobic glycolysis, CN has high aff for Fe3+ binds to Fe3+ of cytochrome oxidase, thereby halting ETC and ATP production, CN poisoning symptoms/ signs are signs of cellular hypoxia, CN poisoning symptoms/ signs are bright red venous blood no cyanosis, <math xmlns="http://www.w3.org/1998/Math/MathML"> <mtext> 1. amyl nitrite </mtext> </math> oxidizes Hb (Fe2+) --> Hb (Fe3+) methemoglobin