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This Concept Map, created with IHMC CmapTools, has information related to: therapy for pesticide and drug poisoning, serum Fe levels: 0-100ug/mL normal 100-350 definite poisoning no treatmen because benefits<risk diarrhea hypotension tachycardia, mit memb damage ???? decr ox phosph, iron poisioning symptoms/ signs are metabolic acidosis, thrombin inhibits coagulation, mit memb damage causes apoptosis, hydroxyl radicals from hydrogen peroxide lipid peroxidation mit memb damage, decr ox phosph ???? compens glycolysis, corrosive effect of Fe causes erosion & ulceration in stomach and intestines, free Fe inhibits thrombin, compens glycolysis ???? incr lactic acid, iron poisioning symptoms/ signs are GI irriation and bleeding, liver stores Fe in ferritin, Fe-storage protein, iron poisioning mechanism corrosive effect of Fe, liver too much Fe, release into free Fe form, necrosis mit memb damage, iron poisioning sources are iron pills, usu toddlers. TD = 21-60mg/kg LD >= 60mg/kg 1g lethal, chelators make metal ions more soluble, allowing easier excretion by kidneys, serum Fe levels: 350-500 pot. serious toxicity 500-1000 def serious toxicity +1000 pot. fatal treatment benefits>risks deferoxamine (Fe chelator), iron poisioning mechanism transferrin (Fe-carrying protein) saturates, iron poisioning toxicity diagnosed 2-4hrs post- ingestion by serum Fe levels: 0-100ug/mL normal 100-350 definite poisoning, iron poisioning symptoms/ signs are pulmonary edema, death