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This Concept Map, created with IHMC CmapTools, has information related to: therapy for pesticide and drug poisoning - Pb poisioning, Pb poisoning mechanism complexes w/ -OH, -SH, -NH2, dimercaprol (for removal in soft tissue) i.m. functions by 1. chelating metals via sulfhydryls 2. undergo rapid oxidation 3. used to treat As, Au, Hg 4. used w/ CaNa2EDTA for Pb, Pb poisoning signs and symptoms in adults: 1. peripheral neuropathy (demyelination) 2. kidney (prox tubule damage and hypertension), Pb poisoning treatment calcium disodium EDTA (edetate calcium disodium) for removal in blood, Pb poisoning signs and symptoms hypochromic microcytic anemia, Pb chem. sim to Ca2+ stored in bone 90%, Pb poisoning signs and symptoms in children: 1. encephalopathy 2. asymptomatic, Pb poisoning diagnosis blood Pb levels, Pb poisoning signs and symptoms GI problems: abd pain & loss of appetite9, Pb poisoning mechanism inhibits activity of enzymes w/ sulfhydryl groups at active sites, calcium disodium EDTA (edetate calcium disodium) for removal in blood description Ca2+ - chelated complex, Pb poisoning treatment dimercaprol (for removal in soft tissue) i.m., dimercaprol (for removal in soft tissue) i.m. drawback high toxicity, Pb poisoning sources lead-containing objects: paint containers (crystal) contaminated water solder, lead industry, Pb poisoning mechanism results in leaky capillary, Pb poisoning treatment penicillamide (less severe), Pb poisoning absorption via GI: nonindustrial lungs: industrial, inhibits activity of enzymes w/ sulfhydryl groups at active sites results in heme synthesis inhibition, hypochromic microcytic anemia associated w/ incr delta-aminolevulinate in urine (ɬ.5mg/dL) accumulation of protoporphyrin IX (basis for free erthrocyte protopophyrin (FEP) test; indicates chronic exposure (ɭmo), results in leaky capillary results in leak of plasma, brain edema develops, incr intracranial pressure...