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This Concept Map, created with IHMC CmapTools, has information related to: therapy for pesticide and drug poisoning - chlorinated aromatic hydrocarbons, chlorinated aromatic hydrocarbons poisoning (e.g. dioxin) mechanism 1. binds to arylhydrocarbon receptor ... 2. induces transcription/translation of Ah hydroxylase (correlates w/ toxicity), chlorinated aromatic hydrocarbons poisoning (e.g. dioxin) mechanism enterohepatic recirculation, chlorinated aromatic hydrocarbons poisoning (e.g. dioxin) treatment cholestyramine prevents CAH reabsorption (also used w/ warfarin), cholestyramine prevents CAH reabsorption (also used w/ warfarin) works by removing bile acid (-) required for CAH adsorption into intestinal epi cell from lumen, chlorinated aromatic hydrocarbons poisoning (e.g. dioxin) mechanism incr delta-Aminolevolinate synthase -> incr protoporphyrin IX -> incr porphyrins, chlorinated aromatic hydrocarbons poisoning (e.g. dioxin) signs and symptoms Porphyria: skin lesions (poisoned politician), photosensitivity, hyperpigmentation, chlorinated aromatic hydrocarbons poisoning (e.g. dioxin) sources herbicides (Agent Orange), incr delta-Aminolevolinate synthase -> incr protoporphyrin IX -> incr porphyrins Porphyria Porphyria: skin lesions (poisoned politician), photosensitivity, hyperpigmentation