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This Concept Map, created with IHMC CmapTools, has information related to: Autacoids 1, lipoxygenase inhibitor zileuton (Zyflo) use bronchodilator treatment for asthma/ allergic reactions, clinical corr: If take aspirin (COX inhb) for years soln: take selective COX2 inhbtrs: celecoxib (Celebrex), eicosanoids pharmacokinetics distribution stored&released as needed, PGE2 incrs uterine, LTD4 incrs pain, PGE2 relaxes bronchial muscles, TXa2 incrs platelet agg, selective COX2 inhbtrs: celecoxib (Celebrex) not in use anymore, because of incrsd risk of MI from imbalance of COX1/COX2 COX1 in platelets catlyz TXA2/incrs thrombosis COX2 in endothl catlyz PGI2/redcs thrombosis, "good" PG's that reslt in incrs cAMP are PGI2 prostacyclin, "bad" PG's that rslt in PLC-Ca2+ incrs are TXa2, non selective COX1-COX2 inhibitors clinical uses anti-pyretic analgesic, PGE2 decrs platelet aggrtn, LT is bronchoconstrictor, PGI2 prostacyclin relaxes bronchial muscles, PGE2 incrs mucus secretions, selective COX2 inhbtrs: celecoxib (Celebrex) not in use anymore, because of incrsd risk of MI rofecoxib (Vioxx), clinical corr: If take aspirin (COX inhb) for years blocks production of mucus secretions, PGF2 contracts GI smooth muscle, PGF2 can cause diarrhea, lipoxygenase inhibitor zileuton (Zyflo) prevents synthesis of LT, PGI2 prostacyclin dilates vasculature