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This Concept Map, created with IHMC CmapTools, has information related to: Richard Dilworth concept map, Richard Dilworth is 33 y/o, hypercellularity in bone marrow, cell turn over rate leads to increased purine nucleotide metabolism, hematopoetic stem cells, myeloid origin which are produced in bone marrow, Philadelphia Chromosome is characteristic of Chronic Myelogenous Leukemia, Philadelphia Chromosome is a Translocation between chromosome 9&22, Increased HgB/Hematocrit which leads to increased breakdown of blood cells in the spleen, Neutrophils express elevated B12 binding protein, increased breakdown of blood cells in the spleen which leads to splenomegaly, hematopoetic stem cells, myeloid origin which results in Increased HgB/Hematocrit, Richard Dilworth Initially presented with gradual onset Elevated WBC, Bcl-abl is a non receptor tyrosine kinase, Translocation between chromosome 9&22 which creates Bcl-abl, Chronic Myelogenous Leukemia increases hematopoetic stem cells, myeloid origin, Bcl-abl which inhibits cell cycle regulation, increased purine nucleotide metabolism leads to elevated plasma uric acid, Elevated WBC especially Neutrophils, cell cycle regulation which stimulates unregulated growth of hematopoetic stem cells, myeloid origin, Imantinib inhibits activity of Bcl-abl, elevated B12 binding protein causes elevated B12