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This Concept Map, created with IHMC CmapTools, has information related to: Untitled, Richard Dilworth Initially presented with gradual onset Increased HgB/Hematocrit, DNA damage during cell cycle regulation, immature blood cells which results in Left-Shifted Blood Smear, Richard Dilworth Initially presented with gradual onset elevated plasma uric acid, Hematopoietic cell transplantation replace cells with Philadelphia Chromosome, Bcr-abl indirectly upregulates JAK/STAT transcriptional activators, JAK/STAT transcriptional activators which stimulates unregulated growth and proliferation of hematopoetic stem cells, myeloid origin, Richard Dilworth Initially presented with gradual onset elevated B12, Bcr-abl downregulates gene BRCA1, elevated B12 binding protein causes elevated B12, Richard Dilworth Initially presented with gradual onset fatique, Bcr-abl which inhibits DNA repair, Ras (proto-oncogene) which stimulates unregulated growth and proliferation of hematopoetic stem cells, myeloid origin, bone marrow releases immature blood cells, Philadelphia Chromosome is characteristic of Chronic Myelogenous Leukemia, hematopoetic stem cells, myeloid origin which are produced in bone marrow, increased breakdown of blood cells in the spleen which leads to splenomegaly, Chronic Myelogenous Leukemia in late stages resembles Acute Myeloid Leukemia, Richard Dilworth is exercise instructor, Elevated WBC especially Neutrophils