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This Concept Map, created with IHMC CmapTools, has information related to: Final Richard Dilworth concept map, 144 lbs. , 5'9'' but now lost 10 lbs., Richard Dilworth Initially presented with gradual onset LUQ fullness, hematopoetic stem cells, myeloid origin which results in Left-Shifted Blood Smear, hypercellularity in bone marrow, bone marrow releases immature blood cells, elevated B12 binding protein causes elevated B12, Richard Dilworth Initially presented with gradual onset Left-Shifted Blood Smear, Richard Dilworth Initially presented with gradual onset fatique, splenomegaly detected by CT scan, Bcr-abl which inhibits DNA repair, Bcr-abl which inhibits cell cycle regulation, Neutrophils express elevated B12 binding protein, Ras (proto-oncogene) which stimulates unregulated growth and proliferation of hematopoetic stem cells, myeloid origin, immature blood cells which results in Left-Shifted Blood Smear, Richard Dilworth Treated with Blood Transfusion (Late stage option), Philadelphia Chromosome is a Translocation between chromosome 9&22, Richard Dilworth Initially presented with gradual onset elevated plasma uric acid, Richard Dilworth Initially presented with gradual onset Elevated WBC, Imantinib inhibits activity of Bcr-abl, hematopoetic stem cells, myeloid origin which results in Elevated WBC