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This Concept Map, created with IHMC CmapTools, has information related to: 1.17 Bchem Tangier disease, CAD due to low LDL level (40% of normal), abnormal neurological findings which include upper limb reflexes (1/4 and 2/4), ABCA-1 gene located on exon 12, high plasma triacylglycerol levels due to absence of ApoC2, IDL intermediate between VLDL, immune response including release of leukocytes, full of foam cells further enhancing immune response, 32 yo Male lipid profile includes very low plasma HDL levels, Homozygotes display only clinical phenotypes, Family History which includes Mother, immune response leading to atherosclerotic plaque, ATP-binding cassette transporter stimulates association of cholesterol, oxidized LDL in tunica intima further enhancing immune response, Homozygotes do not have a risk of CAD, LDL by CETP, Heterozygotes have one functional ABCA1 allele, Mother who also has very low plasma HDL levels, ATP-binding cassette transporter stimulates intracellular pooling of cholesterol, immune response including release of monocytes, ATP-binding cassette transporter stimulates cell uptake of apoA-I