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This Concept Map, created with IHMC CmapTools, has information related to: 1.17 Biochem - Tangier Disease (rearranged), HDL levels half normal sufficient for ApoC-II, 32 yo Male exam findings include abnormal neurological findings, tunica intima eventually necrose, foam cells in tunica intima, Nascent, Discoidal HDL prevents formation of mature HDL, LDL receptors and taken up by Liver, low plasma Cholesterol levels consistent with homozygous form, ATP-binding cassette transporter (ABCA1) prevents assembly of Nascent, Discoidal HDL, lipoprotein lipase degrades Triacylglycerides, tissue hyperplasia by actively clearing elevated cholesterol esters, high plasma triacylglycerol levels consistent with homozygous form, LDL contains ApoB-100, low plasma LDL levels decreased formation of oxidized LDL, ROS forming oxidized LDL, 32 yo Male lipoprotein and lipid profiles revealed low plasma Cholesterol levels, loss of temperature and pain sensation (radial and median nerves) biopsy found lipid deposits, consanguinity in parents' and grandparents' generations consistent with homozygous form, Triacylglycerides contributing to high plasma triacylglycerol levels, low plasma Cholesterol levels consistent with heterozygous form, cellular cholesterol to Lipid-poor ApoA-1