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This Concept Map, created with IHMC CmapTools, has information related to: B4 Gaucher Disease, ceramide used to assemble glycosphingolipids, Liver causing hepatomegaly, glucocerebroside used to degrade membranes of leukocytes, erythrocytes, and platelets, membranes of leukocytes, erythrocytes, and platelets which can cause anemia, Type I Gaucher disease in 4-year-old female, 81% reduction in normal enzymatic activity of glucocerebrosidase, bony infarcts increasing likelihood of bone crises, osteopenia increasing likelihood of bone crises, hydrolases in lysosomes of macrophages, lysosomes of macrophages to eventually become glucocerebroside, glucocerebrosidase resulting in accumulation of glucocerebroside, allelic variant N370S resulting in heteroallelic, oligosaccharide chains disassembled by hydrolases, 4-year-old female could be treated with Ceredase, allelic variant IVS2+1 G to A resulting in heteroallelic, Ceredase derived from placentas, glucocerebrosidase to ceramide, bone marrow may lead to bony infarcts, increased rate of destruction of membranes of leukocytes, erythrocytes, and platelets, allelic variant IVS2+1 G to A on gene coding for glucocerebrosidase