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This Concept Map, created with IHMC CmapTools, has information related to: Hypothyroidism 4.18.12, defective TSH receptor leading to decreased sythesis of thyroglobulin, Todd Wilson presents with 20 lbs weight gain, thyroid growth contradicting finding of non-palpable thyroid, Bradycardia and decreased cardiac contractility which causes Low stroke volume and decreased cardiac output, reduced T3/T4 leads to Decreased protein synthesis within cells, Decreased protein synthesis within cells causes reduced growth of skin, hair and nails, reduced T3/T4 resulting in decreased metabolic rate, Todd Wilson lab findings reveal elevated TSH 97.47 mg/dL (normal = 0.34-5.6), Todd Wilson presents with Non pitting periorbital edema, decreased TPO which reduces Iodination of thyroglobulin, decreased linkage with glycosaminoglycans resulting in excess free glycosaminoglycans, elevated TSH 97.47 mg/dL (normal = 0.34-5.6) normally regulated by negative feedback loop, depression due to lethargy, defective TSH receptor leading to reduced iodide uptake, decreased excitability of neurons causing bradycardia (below 60 bpm), decreased sythesis of thyroglobulin which reduces Iodination of thyroglobulin, Primary hypothyroidism treated with T4 replacement therapy, Todd Wilson presents with Nails thin and broken, reduced T3/T4 stimulates release of TSH, decreased heat production resulting in Low core body temperature (97.8)