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This Concept Map, created with IHMC CmapTools, has information related to: LAST CBL EVER!, decreased physiological response to insulin in Adipose tissue, mesolimbic cholenergic -dopaminergic reward system resulting in Compulsive eating, Fructose-6-P leading to increased gluconeogenesis, Patient 48-y/o-female presents with extreme fatigue, NADH leading to decreased GNG substrate, Patient 48-y/o-female that is physician, obesity via Reduction of weight through lifestyle modifications, Free Fatty Acids which is transported to the liver, VLDL which can lead to Plaque formation, Consider pharmacological therapy of orlistat, downregulating tyrosine kinase receptor when bound to insulin normally leads to phosphorylation of insulin receptor, POMC/CART system stimulated by Adiponectin, acetyl-CoA leading to decreased GNG substrate, F-1,6-BP to Fructose-6-P, elevated triglycerides are 4 out of the 5 criteria of metabolic syndrome, elevated fasting glucose are 4 out of the 5 criteria of metabolic syndrome, Leptin via Indirect mechanism, Patient 48-y/o-female lab findings include elevated triglycerides, Patient 48-y/o-female presents with blurred vision, glucose-6-phosphate leading to decreased pyruvate