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This Concept Map, created with IHMC CmapTools, has information related to: Diabetic_Nephropathy_CMAP_v1, Primary endpoint is_composite_of Increased serum creatinine concentration, Therapeutic Efficacy Point are described by Observation or Assessment, Secondary efficacy endpoints (e.g. Myocardial infarction) are denoted by italicized font, Concepts in other TAs (e.g. Stroke) are denoted by Underlined text, Instances of concepts (e.g. Age) are denoted by Square-edged rectangles, Therapeutic Efficacy Point are described by Physiological processes, Secondary endpoint is_composite_of Myocardial infarction, Secondary endpoint is_composite_of Proteinuria, First hospitalization for heart failure is_instantiated_by Hospitalization, Covariates include Age Gender Ethnicity BMI Blood pressure Insulin use CV disease history Retinopathy Serum creatinine Urinary protein excretion Urinary albumin excretion Glycosylated hemoglobin, Secondary endpoint is_composite_of Peripheral revascularization, Increased serum creatinine concentration measures Serum creatinine (SCr), Primary endpoint is_composite_of Onset of end stage renal disease, Repeated concepts/instances (e.g. Hospitalization) are denoted by dotted outline, Secondary endpoint is_composite_of First hospitalization for unstable angina, Rate of progression of renal disease is_indicated_by Increased serum creatinine concentration, Increased serum creatinine concentration is_measured_between Defined timepoints, Secondary endpoint is_composite_of First hospitalization for heart failure, Secondary endpoint is_composite_of Coronary revascularization, Secondary endpoint is_composite_of Stroke