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This Concept Map, created with IHMC CmapTools, has information related to: GI Week 2, ABCA1 Increases HDL, Lifestyle control of cholesterol Control HDL through Exercise, Lipolysis then Vesicle formation/mixed micelle formation, isopentenyl pyrophosphate farnesyl pyrophosphate, HMG CoA reduced by HMG CoA reductase, Exercise Up-regulates ABCA1, PCSK9 gain of function mutation results in familial hypercholesterolemia, Cholesterol synthesis occurs in cytosol, familial hypercholesterolemia because mutation in B-100 --> LDL cannot bind LDLR, cholesterol via LDLR-mediated endocytic uptake uptake by peripheral cells, Membrane integration then Re-synthesis, hypobetalipoproteinemia because chylomicrons and LDL cannot be synthesized, 3 acetyl CoA form HMG CoA, Re-synthesis then Chylomicron packaging, Diffusion then Re-synthesis, statins are selective competitive inhibitors for HMG CoA reductase, Genetic determinants of cholesterol levels PCSK9, HMG CoA reductase regulated by cholesterol 27C, Weight loss Decreases LDL, HMG CoA reductase regulated by covalent modification