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This Concept Map, created with IHMC CmapTools, has information related to: Cardiac Output Cmap, Cardiac Output is directly affected by Stroke Volume, Cardiac Output is directly affected by Heart Rate, venous return is directly affected by blood volume, ESV inversely affected by Stroke Volume, Heart Rate increases with positive chronotrophic agents, venous return is directly affected by venous pressure, preload due to EDV is directly affected by venous return, ESV directly affects afterload, venous return is inversely affected by intrathoracic pressure, Stroke Volume is directed affected by preload due to EDV, Stroke Volume is directed affected by contractility, Heart Rate deceases with negative chronotrophic agents, preload due to EDV is directly affected by filling time, Heart Rate inversely affects filling time, contractility decreases with negative inotrophic agents, Stroke Volume is inversely affected by afterload, contractility increases with positive inotrophic agents