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This Concept Map, created with IHMC CmapTools, has information related to: Cardiac Output, contractility decreases with negative inotropic agents, Heart Rate inversely affects filling time, ESV inversely affects Stroke Volume, Heart Rate increases with positive chronotropic agents, Cardiac Output is affected by Heart Rate, preload due to EDV is directly affected by venous return, Heart Rate decreases with negative chronotropic agents, Cardiac Output is affected by Stroke Volume, venous return is inversely affected by intrathoracic pressure, Stroke Volume is directly affected by contractility, Stroke Volume is directly affected by preload due to EDV, preload due to EDV is directly affected by filling time, contractility increases with positive inotropic agents, venous return is directly affected by blood volume, Stroke Volume is inversely affected by Afterload, venous return is directly affected by venous pressure, Afterload directly affects ESV