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This Concept Map, created with IHMC CmapTools, has information related to: retreat CMAP, venous return is directly affected by venous pressure, Cardiac output is directly affected by heart rate, heart rate decreases with negative chronotrophic agents, venous return is inversely affected by intrathoracic pressure, heart rate increases with positive chronotrophic agents, afterload directly affects ESV, contractility increases with positive inotropic agents, contractility decreases with negative inotropic agents, Stroke volume is directly affected by contractility, preload due to EDV is directly affected by ????, Stroke volume is directly affected by preload due to EDV, preload due to EDV is directly affected by venous return, Cardiac output is directly affected by Stroke volume, Stroke volume is inversely affected by afterload, heart rate inversely affects filling time, venous return is directly affected by blood volume, Cardiac output is directly affected by Stroke volume, preload due to EDV is directly affected by ????, ESV inversely affects ????