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This Concept Map, created with IHMC CmapTools, has information related to: AmyWallaceTutorial, cardiac output is directly affected by heart rate, heart rate increases with positive inotropic agents, preload due to EDV is directly affected by venous return, contractility increases with positive inotropic agents, cardiac output is directly affected by stroke volume, venous return is directly affected by venous pressure, contractility decreases with negative inotropic agents, stroke volume is directly affected by preload due to EDV, preload due to EDV is directly affected by filling time, stroke volume is inversely affected by afterload, stroke volume is directly affected by contractility, venous return is inversely affected by intrathoracic pressure, venous return is directly affected by blood volume, stroke volume inversely affects ESV, ESV directly affects afterload, heart rate decreases with negative inoptropic agents, heart rate inversely affects filling time