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This Concept Map, created with IHMC CmapTools, has information related to: 12102014 Vitamin B12, Absoprtion requires Haptocorrin (salivary glands) Intrinsic factor and pepsin (stomach) Receptor protein cubulin (enterocytes) Transcobalin II (plasma transporter), Vitamin B12 an essential vitamin Absoprtion, Vitamin B12 an essential vitamin involved in reactions homocysteine--> methionine, Methionine regeneration B12 deficiency Folate (invoved in rxn) is depleted impairing DNA synthesis, Methylmalonyl CoA converted to Succinyl CoA B12 deficiency Build up of methylmalonyl--> Abnormal fatty acids in neuronal membranes, homocysteine--> methionine Methionine = methyl source for methylation reactions, homocysteine--> methionine Folate used in this reaction, thus with B12 deficiency folate levels can fall, Absoprtion occurs in Ileum, Folate used in this reaction, thus with B12 deficiency folate levels can fall Folate = necessary for DNA synthesis, with deficiency rapidly dividing cells suffer eg. erthyropoeisis, Vitamin B12 an essential vitamin involved in reactions Methylmalonyl CoA converted to Succinyl CoA