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This Concept Map, created with IHMC CmapTools, has information related to: Module 2 - Epilepsy & Nav1.1 class map, Nav1.1 is a dominant mutation, seizures Because GABA is not being released, cerebellum involved in controlling Balance and coordination, the occurance of 2+ unprovoked seizures w/in one's lifetime seizure mechanisms include Ions and membranes, only 50% of gene product is formed Can lead to Disorders, only 50% of gene product is formed which is caused by frameshift mutation, Immunoflouresence shown in Fig 6, heterozygous mutant mice found to have slightly longer life expectancy, abnormal, rhythmic and synchronous discharges of excitatory electrical activity within the brain which includes types such as GEFS+, ICEGTC, SMEIF, neocortex shows that Nav1.1 is found in layers II and III in AIS of GABAergic neurons, Exon 21 in the Scn1a gene, haploinsufficient causes seizures, Scn1a gene is analogous to SMEI Mutation, heterozygous mutant mice also had a recorded spike decrement, location of AP initiation contain phosphorylated neurofilaments, Immunoflouresence shown in Fig 5, Immunoflouresence shown in Fig 7, an additional study to explore if specific sodium channels can be blocked/activated, Neurons fire uncontrolably in the brain Can lead to loss of control in muscles, AISs & PV interneurons as demonstrated by Immunoflouresence