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This Concept Map, created with IHMC CmapTools, has information related to: Module 2 - Epilepsy & Nav1.1 class map - revised, potential human targets and therapies perhaps by altering the glutamate/glutamine cycle in astrocytes and neurons to decrease glutamate transmission, Immunoflouresence shown in Fig 7, only 50% of gene product is formed which is caused by nonsense mutation, the occurance of 2+ unprovoked seizures w/in one's lifetime caused by alterations in Neural network, Immunoflouresence which use beta-4-spectrin, of the spike decrement leading the researchers to conclude that Inhibitory neurons can't fire enough APs to properly inhibit excitatory neurons, the occurance of 2+ unprovoked seizures w/in one's lifetime caused by alterations in Ions and membranes, cerebellum involved in controlling Balance and coordination, Used antibodies to probe proteins for Immunoflouresence, AISs of PV interneurons as demonstrated by Immunoflouresence, the focus of the study and could lead to an additional study to, Immunoflouresence which use phosphorylated neurofilaments, cerebellum specifically Purkinje cell somata, there's an underlying imbalance of excitation and inhibition Can lead to loss of control in muscles, altering the expression of related channels such as Nav1.2 or Nav1.3, Fig 7 looks at cerebellum, only 50% of gene product is formed Can lead to Disorders, spike decrement seen in fig 8, Maintenance of fast spiking interneurons releasing GABA demonstrated by injecting the neurons with current, heterozygous mutant mice display a lower membrane potential compared to WT