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This Concept Map, created with IHMC CmapTools, has information related to: GPR39 paper, excitatory neurotransmission which leads to increases glutamtae release, whole cell patch clamps which helped determine Excitatory/inhibitory frequency ratio, TC-G 1008 doesn't affect saccaharin intake / preference, inhibtory neurotransmission measured using whole cell patch clamps, uncontrolled drug-use which causes depression of CNS, mice treated with TC-G 1008 agonist treated with TC-G 1008, less ethanol intake shown in fig 3, Excitatory/inhibitory frequency ratio measured in fig. 4, g-protein coupled, metabotropic receptor that modulates inhibtory neurotransmission, there is an imbalance of inhibition and excitation pathways within the nucleus accumbens, people with depression but is upregulated in people taking antidepressants, GPR39 Gene is a g-protein coupled, metabotropic receptor, rewiring of synaptic/ neuronal circuits in the brain essential to learning, TC-G 1008 reduces grehlin Grehlin receptor, neuroplasticity defined as rewiring of synaptic/ neuronal circuits in the brain, treatment FDA drugs naltrexone, TC-G 1008 doesn't affect locomotor activity, g-protein coupled, metabotropic receptor highly involved in people with depression, GPR39 Gene Linked to GI function, no reduction in total fluid intake shown in fig 3