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This Concept Map, created with IHMC CmapTools, has information related to: Creb Stress & Depression, Volcano Plot which narrowed down the results, Depression diagnosis requires specific symptoms over 2 week period, Depression shown to be related to Creb, injecting the AAV-Cre virus in order to knockout CREB, TLR1 found using Volcano Plot, unpredictable social and physical stressors by procedures such as water restriction, UCMS led to decreased core body temperature in GFP mice, Depression is a disorder characterized by depressed mood, anhedonia which is the inability to feel pleasure, elevated cortisol leads to decreased serotonin, reguates thousands of genes shown with TRAP (translating ribosome affinity purification), Stress causes overactivation of ANS, genes that were affected in CREB absence induced downregulation of immune system, Stress was induced in mice via UCMS, Stress was measured by amount of nestlet shredding, Stress was measured by Forced Swimming Test, UCMS which involves causing unpredictable social and physical stressors, TRAP (translating ribosome affinity purification) done in fig 2, Stress shown to have elevated cortisol, wild type mice had their whole genome sequenced