WARNING:
JavaScript is turned OFF. None of the links on this concept map will
work until it is reactivated.
If you need help turning JavaScript On, click here.
This Concept Map, created with IHMC CmapTools, has information related to: Creb Stress & Depression - b, RNA sequencing techniques narrowed relevant pathways that Creb particpated in via Volcano Plot, Volcano Plot which narrowed down the results, narrowed down the results to genes that were affected in CREB absence, elevated cortisol causes changes in the Hippocampus, genes that were affected in CREB absence induced downregulation of inflammatory response, genes that were affected in CREB absence induced downregulation of GTP Binding, TLR1 was increased after UCMS, Stress is defined as a physical, mental, or emotional factor that causes bodily or mental tension, Hippocampus was done by injecting the AAV-Cre virus, anhedonia, lack of pleasure, lack of interest both can be interpreted in a variety of ways, TRAP (translating ribosome affinity purification) done in fig 2, toll-like receptors like what happens when down or upregulated, Depression shown to be related to Creb, Decrease in sucrose preference in Creb deleted mice shown in Figure 4 B,C,D, Stress was measured by amount of nestlet shredding, knockout CREB creating CREB- deficient mice, TLR1 found using Volcano Plot, narrowed down the results to genes with large fold change, that prototypical mice enjoy doing increased shredding may show anxiety-like behavior, Depression leads to Psychological/ Phisiological changes