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This Concept Map, created with IHMC CmapTools, has information related to: PERIO CONCEPT MAP, Thorough and effective brushing required to disrupt plaque, Apical migration of epithelium in order to move away from the plaque (etiologic agent), Presence of 5% inflammatory infiltrates such as Lymphocytes, Histopathologic Features such as Apical migration of the junctional epithelium, Periodontitis exhibits Histopathologic Features, Phases in the Pathogenesis which are 3. (Specific) Immune Response Phase, 1. Acute Bacterial Challenge Phase where bacteria attaches to host cell and enters the tissue, different cell receptors to Leukocytes, bacterial components and virulent factors such as fMLP Proteases, Histopathologic Features such as Extension of epithelial rete pegs deeper into the connective tissue, different cell receptors to endothelial cells, Histopathologic Features such as Increase in GCF production, Histopathologic Features such as Extension of inflammatory infiltrates laterally and apically, Continued loss of collagen to increase space available for infiltrates, Histopathologic Features such as Alveolar bone loss, bacterial components and virulent factors such as Peptidoglycan, neutrophils which indicates chronic inflammatory response, bacterial components and virulent factors such as Fimbriae, Histopathologic Features such as Extensive damage to periodontal fibers, Cinically healthy gingiva composed of Mainly Gram (+) Facultative anaerobes