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This Concept Map, created with IHMC CmapTools, has information related to: PERIO CONCEPT MAP oct 6 12.32am, B-Cells to proliferate Will mature to Plasma cells, binding site for continually growing bacteria, Biofilm Formation characteristics Homeostasis, Highly pathogenic periodontal bacteria such as Tanerrella forsythia Aggregatibacter actinomycetemcomitans Porphyromonas gingivalis Treponema denticola, 3. (Specific) Immune Response Phase Happens when Inflammation is insufficient to contain the bacterial challenge, Plasma cells Will then produce Antibodies, Early Gingivitis without mechanical disruption of biofilm, Cinically healthy gingiva may have Biofilm Formation, T-Helper 1 cell Will produce IFN-y, Established Gingivitis can progress to Periodontitis, junctional epthelium towards the gingival sulcus, Extracellular matrix production from Carbohydrate sources, selectins binding to surface adhesion glycoproteins, IL-10 Will induce B-Cells to proliferate, Recognition of foreign antigens by specific lymphocyte Starts when Antigen-Presenting cells (ex. macrophage, B-cells, dendritic cells, langerhans cells), blood vessels after diapedesis or adhesion to the walls of the endothelium, high cellular turnover indicating rapid changes, continually growing bacteria in intermicrobial matrix, Increase thichness of biofilm causing More difficult diffusion, Presence of 5% inflammatory infiltrates such as Macrophages